A 3 Ferrocenophane Polyphenol Showing a Remarkable Antiproliferative Activity on Breast and Prostate Cancer Cell Lines

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TitleA 3 Ferrocenophane Polyphenol Showing a Remarkable Antiproliferative Activity on Breast and Prostate Cancer Cell Lines
Publication TypeJournal Article
Year of Publication2009
AuthorsPlazuk, D, Vessieres A, Hillard EA, Buriez O, Labbe E, Pigeon P, Plamont MA, Amatore C, Zakrzewski J, Jaouen G
JournalJournal of Medicinal Chemistry
Volume52
Issue15
Pagination4964-4967
Date PublishedAug
ISBN Number0022-2623
Accession NumberISI:000268661600042
Abstract

We have previously shown that modification of polyphenols with a ferrocenyl group call dramatically enhance their cytotoxicity. We now present two new [3]ferrocenophane compounds, one of which has an antiproliferative effect seven times stronger than the corresponding noncyclic species, with IC50 values of 90 and 94 nM on hormone-independent MDA-MB-231 breast and PC-3 prostate cancer cell lines, respectively. Solubility studies in water using methylated P-cyclodextrin and electron transfer studies are also presented.

URL<Go to ISI>://000268661600042
DOI10.1021/jm900297x
Short TitleA 3 Ferrocenophane Polyphenol Showing a Remarkable Antiproliferative Activity on Breast and Prostate Cancer Cell Lines
Unit: 
UMR 8640