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Mapping molecules inside cells is a contemporary challenge that requires both high sensitivity and sub-micrometric resolution. IR-spectroscopy is valuable for chemical imaging. In the case of vibrational excitation in the IR, no photobleaching is induced, in contrast to what is observed with organic fluorophores in the visible or UV range. IR is already used for tissue-mapping and characterization, but reach subcellular detection is not trivial. With optical detection, because of diffraction limit, the resolution in the IR cannot be better than 1 to 2 µm.
Résumé: 

Mapping molecules inside cells is a contemporary challenge that requires both high sensitivity and sub-micrometric resolution. IR-spectroscopy is valuable for chemical imaging.

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Equipe 4
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Références: 
Subcellular Imaging in the mid-IR of a Metal-Carbonyl Moiety using Photothermal Induced Resonance, Clotilde Policar*, Jenny-Birgitta Waern, Marie-Aude Plamont, Sylvain Clède, Céline Mayet, Rui Prazeres, Jean-Michel Ortega, Anne Vessières, Alexandre Dazzi, Angew. Chemie, Int. Ed., 2011, 860