Titanium-Catalyzed Cyclopropanation of Boc-Protected Cyanohydrins: A Short Access to Aminocyclopropanecarboxylic Acid Derivatives

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TitleTitanium-Catalyzed Cyclopropanation of Boc-Protected Cyanohydrins: A Short Access to Aminocyclopropanecarboxylic Acid Derivatives
Publication TypeJournal Article
Year of Publication2010
AuthorsPearson-Long, MSM, Beauseigneur A, Karoyan P, Szymoniak J, Bertus P
JournalSynthesis-Stuttgart
Issue20
Pagination3410-3414
Date PublishedOct
ISBN Number0039-7881
Accession NumberISI:000283494400002
Abstract

The preparation of protected 1-aminocyclopropanecarboxylic acid was performed from readily available and inexpensive starting materials, using titanium-catalyzed cyclopropanation as the key step. As an extension of this methodology, a diastereoselective synthesis of the cis-2-vinyl-substituted analogue is presented.

URL<Go to ISI>://000283494400002
DOI10.1055/s-0030-1258260
Short TitleTitanium-Catalyzed Cyclopropanation of Boc-Protected Cyanohydrins: A Short Access to Aminocyclopropanecarboxylic Acid Derivatives
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