Discovery and Functional Analysis of a 4th Electron-Transferring Tryptophan Conserved Exclusively in Animal Cryptochromes and (6-4) Photolyases

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Müller, P, Yamamoto J, Martin R, Iwai S, Brettel K

 

DOI: 10.1039/C5CC06276D

 

A 4th electron transferring tryptophan in animal cryptochromes and (6-4) photolyases is discovered and functionally analyzed by transient absorption. It yields a much longer-lived flavin-tryptophan radical pair than the mere tryptophan triad in related flavoproteins, questioning the putative role of the primary light reaction of cryptochrome in animal magnetoreception.

 

Résumé: 

 

A 4th electron transferring tryptophan in animal cryptochromes and (6-4) photolyases is discovered and functionally analyzed by transient absorption. It yields a much longer-lived flavin-tryptophan radical pair than the mere tryptophan triad in related flavoproteins, questioning the putative role of the primary light reaction of cryptochrome in animal magnetoreception.

Equipe de rattachement 8640: 
Photochimie Ultrarapide
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