A 3 Ferrocenophane Polyphenol Showing a Remarkable Antiproliferative Activity on Breast and Prostate Cancer Cell Lines

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TitreA 3 Ferrocenophane Polyphenol Showing a Remarkable Antiproliferative Activity on Breast and Prostate Cancer Cell Lines
Type de publicationJournal Article
Nouvelles publications2009
AuteursPlazuk D, Vessieres A, Hillard EA, Buriez O, Labbe E, Pigeon P, Plamont MA, Amatore C, Zakrzewski J, Jaouen G
JournalJournal of Medicinal Chemistry
Volume52
Fascicule15
Pagination4964-4967
Année de publicationAug
Numéro0022-2623
Accession NumberISI:000268661600042
Résumé

We have previously shown that modification of polyphenols with a ferrocenyl group call dramatically enhance their cytotoxicity. We now present two new [3]ferrocenophane compounds, one of which has an antiproliferative effect seven times stronger than the corresponding noncyclic species, with IC50 values of 90 and 94 nM on hormone-independent MDA-MB-231 breast and PC-3 prostate cancer cell lines, respectively. Solubility studies in water using methylated P-cyclodextrin and electron transfer studies are also presented.

URL<Go to ISI>://000268661600042
DOI10.1021/jm900297x
Importer un fichierA 3 Ferrocenophane Polyphenol Showing a Remarkable Antiproliferative Activity on Breast and Prostate Cancer Cell Lines
Unité de rattachement: 
UMR 8640