Bio - Nicolas Delsuc

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Nicolas Delsuc


 

Chargé de Recherche CNRS

ENS, Department of Chemistry, 24 rue Lhomond

Metals in Biology - Inorganic Cellular Chemistry

Short CV

Oct 2010-   Associate researcher. Laboratoire des BioMolécules, UMR7203 UPMC-ENS.  In the Inorganic Cellular Chemistry group within the team 1.
Sept 2009-Sept 2010 Teaching assistant. Laboratoire des BioMolécules, UMR7203 UPMC-ENS. Supervisor: P. Karoyan, Conception of enzyme mimics with foldamers
Nov 2007-Jul 2009 Post-doctoral fellow of the JSPS. Kyoto University, Japan. Supervisor: I. Hamachi, A. Ojida, Development of molecular receptors for specific peptides recognition
Oct 2004-Oct 2007  PhD in Organic chemistry, Bordeaux1 University.   Supervisor: I. Huc, Development of proteomimetic tertiary structures with aromatic oligoamide foldamers
Sept 2006- Sept 2007 Master 2 in Organic chemistry, Bordeaux1 University

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Present interests:

  •           Development of metal complexes mimicking metalloenzyme using peptides as ligands
  •          Development of metal-centered probes for bio-imaging or diagnostic

Research contracts:

  • ANR JCJC Metallopepzyme, 2016-2020 (PI, 221,5 k€). Collaboration : P. Seksik, E. Quevrain (LBM, UMR 7203). Peptide-based metal complexes mimicking metalloenzymes activity
  • PSL chimie Sun, 2015-2017, (CoPI, 100 k€). Collaboration : C. Aimé (LCMCP, UMR7475, Paris). Surface Nanostructuration using silanes self assemblies
  • Actions Incitatives ENS, 2015, (PI, 10 k€). Development of metal-centered probes for the detection and imaging of biomolecules

 

Communication

6 oral communications (2 international), 10 poster communications (4 international)

Patent

C. Policar, N. Delsuc, F. Lambert, H. Bertrand, A.S. Bernard, S. Hostachy, Functionalizable molecular probe for X-Ray fluorescence spectroscopy and multimodal imaging, 2015, EP 15 175 553.5, european patent; PCT Int. Appl. 2017, WO 2017005822A1

Publications

2018

28) L. Henry, N. Delsuc, C. Laugel, F. Lambert, C. Sandt, S. Hostachy, A.-S. Bernard, H. Bertrand, L. Grimaud, A. Baillet-Guffroy, C. Policar, Labeling of hyaluronic acids with a Re-tricarbonyl tag and percutaneous penetration into human skin studied by multimodal Imaging, Bioconj. Chem. 2018, DOI: 10.1021/acs.bioconjchem.7b00825.

27) A. Conte-Daban, V. Ambike, R. Guillot, N. Delsuc, C. Policar, C. Hureau, A metallo pro-drug to target Cu(II) in the context of Alzheimer’s disease, Chem. Eur. J. 2018, DOI: 10.1002/chem.201706049.

2017

26) J. Graffion, D. Dems, M. Demirelli, T. Coradin, N. Delsuc, C. Aimé, An all-in one molecular structure for the one-step synthesis of functional hybrid silica particles with tunable size, Eur. J. Inorg. Chem. 2017, 43, 5047-5051.

25) N. Delsuc, S. Uchinomiya, A. Ojida, I. Hamachi, Host-Guest System Based on Collagen-Like Triple-Helix Hybridization, Chem. Commun. 2017, 6856.

24) S. Hostachy, C. Policar, N. Delsuc, Re(I) carbonyl complexes: Multimodal Platforms for Inorganic Chemical Biology, Coord. Chem. Rev. 2017, 351, 172.

23) E. Mathieu, A.-S. Bernard, N. Delsuc, E. Quevrain, G. Gazzah, B. Lai, F. Chain, P. Langella, M. Bachelet, J. Masliah, P.  Seksik, C. Policar, A Cell-Penetrant Manganese Superoxide Dismutase (MnSOD) Mimic is Able to Complement MnSOD and Exerts an Antiinflammatory Effect on Cellular and Animal Models of Inflammatory Bowel Diseases, Inorg. Chem. 2017, 56, 2545.

2016

22) M. L. Low, L. Maigre, M. I. M. Tahir, E. R. T. Tiekink, P. Dorlet, R. Guillot, T. B. Ravoof, R. Rosli, J.-M. Pagès, C. Policar, N. Delsuc, K. A. Crouse, New insight into the structural, electrochemical and biological aspects of macroacyclic Cu(II) complexes derived from S-substituted dithiocarbazate schiff bases, Eur. J. Med. Chem. 2016, 120, 1.

21) V. H. Y. Ching, I. Kenkel, N. Delsuc, E. Mathieu, I. Ivanovic-Burmazovic, C. Policar, Bioinspired superoxide-dismutase mimics: the effects of functionalization with cationic polyarginines peptides, J. Inorg. Biochem. 2016, 160, 172.

20) S. Hostachy, J.-M. Swiecicki, C. Sandt, N. Delsuc, C. Policar Photophysical properties of a single core multimodal probe for Imaging (SCoMPI) in a membrane model and in cells, Dalton Trans., 2016, 45, 2791.

2015

19) M. L. Low, G. Paulus, P. Dorlet, R. Guillot, R. Rosli, N. Delsuc, K. A. Crouse, C. Policar Synthesis, characterization and biological activity of Cu(II), Zn(II) and Re(I) complexes derived from S-benzyldithiocarbazate and 3-acetylcoumarin, Biometals, 2015, 28, 553.

18) S. Clède, N. Delsuc, C. Laugel, F. lambert, C. Sandt, A. Baillet-Guffroy, C. Policar An easy-to-detect nona-arginine peptide for epidermal targeting Chem. Commun., 2015, 2687.

2014

17) M. L. Low, L. Maigre, P. Dorlet, R. Guillot, J.-M. Pagès, K. A. Crouse, C. Policar, N. Delsuc Conjugation of a New Series of Dithiocarbazate Schiff Base Copper(II) Complexes with Vectors Selected to Enhance Antibacterial Activity, Bioconj. Chem., 2014, 25, 2269.

2013

16) C. Caumes, N. Delsuc, R. B. Azza, I. Correia, F. Chemla, F. Ferreira, L. Carlier, A. Perez Luna, R. Moumné, O. Lequin, P. Karoyan, Homooligomers of substituted prolines and β-prolines: syntheses and secondary structure investigation, New J. Chem. 2013, 37, 1312.

15) C. Mothes, C. Caumes, A. Guez, H. Boullet, T. Gendrineau, S. Darses, N. Delsuc, R. Moumné, B. Oswald, O. Lequin, P. Karoyan 3-Substituted Prolines: From Synthesis to Structural Applications, from Peptides to Foldamers, Molecules 2013, 18, 2307.

14) S. Clède, F. Lambert, C. Sandt, Z. Gueroui, N. Delsuc, P. Dumas, A. Vessières, C. Policar, Synchrotron radiation FTIR detection of a metal-carbonyl tamoxifen analog. Correlation with luminescence microscopy to study its subcellular distribution, Biotechnol Adv. 2013, 393.

2012

13) N. Delsuc, L. Poniman, J.-M. Léger, I. Huc, Assessing the folding propensity of aliphatic units within helical aromatic oligoamide foldamers, Tetrahedron, 2012, 68, 4464.

2011

12) R. Moumné, N. Delsuc, O. Lequin, K. Guitot, C. Mothes, C. Petrel, D. Servent, C. Z. Dong, P. Berthus, J. Szymoniak, P. Karoyan, Development of tools for tine tuning of peptide secondary structures, Syntheses, Structural and pharmacological applications, Biopolymers 2011, 96, 459.

11) N. Delsuc, S. Massip, J.-M. Léger, B. Kauffman, I.Huc, Relative Helix-Helix Conformations in Branched Aromatic Oligoamide Foldamers, J. Am. Chem. Soc. 2011, 133, 3165.

2010

10) K. Guitot, N. Delsuc, C. Mothes, D. Servent, C. Petrel, J.-L.Vasse, P. Bertus, J. Szymoniak, O. Lequin, P. Karoyan, Prolino amino acids: tools in peptide mimics design. Structural and Pharmacological applications Peptide Science 2010, 47th, 25.

9) V. E. Campbell, X. de Hatten, N. Delsuc, B. Kauffmann, I. Huc, J. R. Nitschke, Cascading transformations within a dynamic self-Assembled system, Nature Chem. 2010, 2, 684.

2005-2009

8) V. E. Campbell, X. de Hatten, N. Delsuc, B. Kauffmann, I. Huc, J. R. Nitschke, Interplay of Interactions Governing the Dynamic Conversions of Acyclic and Macrocyclic Helicates, Chem. Eur. J. 2009, 15, 6138.

7) M. Wolffs, N. Delsuc, D. Veldman, N. Vân Anh, R. M. Williams, S. C. J. Meskers, R. A. J. Janssen, I. Huc and A. P. H. J. Schenning, Helical Aromatic Oligoamide Foldamers as Organizational Scaffolds for Photoinduced Charge Transfer, J. Am. Chem. Soc. 2009, 131, 4849.

6) N. Delsuc, T. Kawanami, J. Lefeuvre, A. Shundo, H. Ihara, M. Takafuji, I. Huc, Kinetics of helix handedness inversion: folding and unfolding in aromatic amide oligomers, ChemPhysChem 2008, 9, 1082.

5) N. Delsuc, M. Hutin, V. E. Campbell, B. Kauffmann, J. R. Nitschke, I. Huc, Metal-directed dynamic formation of tertiary structure in foldamer assemblies: orienting helices at an angle, Chem. Eur. J. 2008, 14, 7140.

4) N. Delsuc, F. Godde, B. Kauffmann, J.-M. Léger, I. Huc, The Herringbone Helix: A Noncanonical Folding in Aromatic-Aliphatic Peptides, J. Am. Chem. Soc. 2007, 129, 11348.

3) N. Delsuc, J.-M. Léger, S. Massip, I.Huc, Proteomorphous objects from abiotic backbones, Angew. Chem. Int. Ed. 2007, 46, 214.

2) T. Buffeteau, L. Ducasse, L. Poniman, N. Delsuc, I. Huc, Vibrational circular dichroism and ab initio structure elucidation of an aromatic foldamer, Chem. Commun. 2006, 2714.

1) C. Dolain, J.-M. Léger, N. Delsuc, H. Gornitzka, I. Huc, Probing helix propensity of monomers within a helical oligomer, Proc. Natl. Acad. Sci. (USA) 2005, 102, 16146.