Bio - Clotilde Policar

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Clotilde Policar

Professor at the Ecole Normale Supérieure (ENS), Laboratoire des BioMolécules, UMR 7203

clotilde.policar@ens.fr
Tél : +33 1 44 32 24 20

Fax : +33 1 44 32 24 02
 

Metals in Biology - Inorganic Cellular Chemistry

Since 2016 Deputy director of the Institut de Chimie du CNRS in charge of interdisciplinarity (DAS-INC)
Since 2014 Deputy director of the LBM-UMR 7203 (Laboratoire des BioMolécules), Dean of the studies at the chemistry dpt ENS
Since 2008 Professor, École Normale Supérieure, Paris (France)
2005-08 Associate Professor, Univ. Paris-Sud11 (ICMMO), Orsay (France)
1996-2005 Assistant Professor, Univ. Paris-Sud 11 (ICMMO), Orsay (France)
1996-95 Post-doctoral researcher, CEA - Saclay, Département de Biologie Cellulaire et Moléculaire, URA 1290
1992-95 PhD, Chemistry, Bioinorganic Systems, Université Paris V, UMR 8601, supervizors: Isabelle Artard and Daniel Mansuy
1992 DEA (M2, Master degree) Bioinorganic Systems
1991 Agrégation de sciences physiques, option chimie Teaching degree in physics and chemistry with a major in chemistry
1988-92

Student at ENS Cachan, Master in molecular physical-chemistry, Université Paris-Sud 11

 

Publications :

-More than 70 peer-reviewed articles, 3 patents (1 licenced and extension, 1 under investigation), 2 book chapters upon invitation

-Outreach : 3 articles in science history, 1 article in the Encyclopedia Universalis, 1 book chapter in a multidisciplinary book about the concept of symmetry in different sciences, co-author of a teaching book (experimental chemistry) and of a book of outreach posters (Why?)

 

Communications :

-32 invited conferences in congresses among which 18 in international congresses (dont Gordon Conference Metals in Biology 2016, Eurobic2014, MRIC 2014, SPEC2012, Eurasia2012, CellNanospec2011) and 14 in national congresses, 43 invited seminars in universities, among which 14 in foreign universities (Martinos Center for Imaging Boston, New York Univ., Geneva (2), Heraklion, East China Normal University (2), Fudan (2), Ann Arbor, Northwestern (2)).

-24 oral communications among which 14 in international congresses (CCC38-2008,Eurobic-2010, ISABC11-2011 ; ICBIC16-2013 ; MRIC-2013 ; Biometals 2014; Eurobic16-2014).

 

Teaching :

Dean of the studies at the chemistry department (since Sept. 2014), in charge of the international relationships (since 2009)

Teaching at ENS and Paris VI; additional conferences at Paris-Sud 11, Paris 5-7, EPHE, ENS-Cachan
Current topics : Inorganic Chemistry, Spectroscopies, Bio-inorganic Chemistry, Metals in Biology, History of Chemistry

Past topics: Molecular magnetism, group theory for chemists, bio-organic and bio-inorganic chemistry, enzymatic catalysis

 

Scientific animation

In charge of the group Inorganic Cellular Chemistry

Co-organisation of the Nuit des Sciences et Lettres 2016

FrenchBIC: Chair (2010-2014) and Vice-chair (2015-)

 

Research contracts :

Undergoing
-ANR contracts (French Research National Agency): as PI (MAGIC, 2015-19)
-Fondation pour la recherche médicale, Appels Pionniers de la recherche Etudes Physico-chimiques innovantes pour la biologie et la médecine (2015-2018)
-Fellowship from the Association François Aupetit (2014) (association of patients suffering from inflammatory bowel diseases)
-Paris-Sciences-Lettres research contract structuration of research (PI, 2015-18) : coll. with ESPCI (J. Vinh) and Institut Curie (S. Marco).
 
Former contrats
-ANR contracts (French Research National Agency) as a partner (MnHFPELDOR, PI L. Tabares, 2012-2015; Take Care, PI M. Robert, 2011-13 ; Metabact, PI I. Artaud, 2011-13)
-Research contract CNRS-contract Interdisciplinary work (interface chemistry-physic-biology), support for risky research (2009), (PI C. Policar, coll. A. Dazzi, LCP, U. paris-Sud et A. Vessières, ENSCP) 2009. Subcellular IR spectromicroscopy.
-Starting grant (Action incitative jeunes chercheurs) (PI C. Policar) 2005-2008. Glycoligands and glycocomplexes
 

Keywords in Research:

Bioinorganic chemistry, physical methods, electron paramagnetic resonance, metal transition complexes, magnetism, superoxide dismutase mimics, superoxide, transient MnOO adducts, low-temperature spectroscopies, glycochemistry: glycoligands, chirality at a metal centre, intracellular detection, cell-biology, biophysics, IR-spectromicroscopy

 

Present interests:

SOD-mimics studied at the cell level, IR-spectromicroscopy, Single Core Multimodal Probes for Imaging (M(CO)3))

 

Publications, books, patents

Peer-reviewed articles:

Articles since 2008 -> Local server

Articles before 2008

A new pentadentate ligand forms both a Di- and a mononuclear Mn-II complex: Electrochemical, spectroscopic and superoxide dismutase activity studies
Federico Cisnetti, Anne-Sophie Lefèvre, Régis Guillot, François Lambert, Guillaume Blain, Elodie Anxolabéhère-Mallart, Clotilde Policar
Eur. J. Inorg. Chem. , 2007, 4472-4480 doi : 10.1002/ejic.200601236

Synthesis and cellular uptake of superparamagnetic dextran-nanoparticles with porphyrinic motifs grafted by esterification
Romain Lucas, Robert Granet, Vincent Sol, Caroline Le Morvan, Clotilde Policar, Eric Rivière, Pierre Krausz
e-polymer , 2007, n°089 full text : http://www.e-polymers.org/

Diaqua[methyl 4-O-benzyl-2,3,6-tri-O(2-picolyl)-alpha-D-mannopyranoside]-cobalt(II) bis(perchlorate) monohydrate: partial coordination of a ligand derived from D-mannose
Federico Cisnetti, Régis Guillot, Michel Thérisod, Clotilde Policar
Acta Crystallogr. Sect. C-Cryst. Struct. Commun. , 2007, m201-m203 doi : 10.1107/S0108270107013522

Glycoligands and Co(II) glycocomplexes. Investigation of the variation of the sugar-scaffold on the structure and chirality measured by circular dichroism
Federico Cisnetti, Régis Guillot, Michel Desmadril, Giorgio Pelosi, Clotilde Policar
Dalton Trans. , 2007, 1473-1476 (hot paper) doi : 10.1039/b618714e

Reactivity of Mn-II with superoxide. Evidence for a [(MnOO)-O-III](+) unit by low-temperature spectroscopies
Sihem Groni, Guillaume Blain, Régis Guillot, Clotilde Policar, Elodie Anxolabéhère-Mallart
Inorg. Chem. , 2008, 46, 1951-1953 doi : 10.1021/ic062063+

Glycoligands tuning the magnetic anisotropy of Ni-II complexes
Gaëlle Charron, François Bellot, Federico Cisnetti, Giorgio Pelosi, Jean-Noël Rebilly, Eric Rivière, Anne-Laure Barra, Talal Mallah, Clotilde Policar
Chem.-Eur. J. , 2007, 13, 2774-2782 (highlight) doi : 10.1002/chem.200601560

 Electronic and steric effects in cobalt Schiff bases complexes: Synthesis, characterization and catalytic activity of some cobalt(II) tetra-halogens-dimethyl salen complexes
Aurel Piu, Clotilde Policar, Jean-Pierre Mahy
Inorg. Chim. Acta , 2007, 360, 2139-2144 doi : 10.1016/j.ica.2006.10.040

Characterization of purified green bell pepper hydroperoxide lyase expressed by Yarrowia lipolytica: Radicals detection during catalysis
Mirna Santiago-G‹mez, Catherine Vergely, Clotilde Policar, Jean-Marc Nicaud, Jean-Marc Belin, Luc Rochette and Florence Husson
Enzyme Microb. Technol. 2008 , 41, 13-18 doi : 10.1016/j.enzmictec.2006.11.017

 Synthesis and superoxide dismutase-like activity of new manganese(III) complexes based on tridentate N2O ligands derived from histamine
Federico Cisnetti, Giorgio Pelosi, Clotilde Policar
Inorg. Chim. Acta , 2007, 360, 557-562 doi : 10.1016/j.ica.2006.07.112

Superoxide dismutase-like activity of cobalt(II) complexes based on a sugar platform
François Bellot, Renaud Hardre, Giorgio Pelosi, Michel Thérisod, Clotilde Policar
Chem. Commun. , 2005, 5414-5416 doi : 10.1039/b508893c

Synthesis and X-ray structure of the (MnCl2)-Cl-II and (MnF2)-F-III complexes of N,N '-dimethyl-2,11-diaza[3,3](2,6)pyridinophane. High-field electron paramagnetic resonance and density funtional theory studies of the Mn(III) complex. Evidence for a low-lying spin triplet state
Ricardo Carina, Belène Albela, Clotilde Policar, Sandrine Poussereau, Joan Cano, Jean Guilhem, Luba Tchertanov, Geneviève Blondin, Michel Delroisse, Jean-Jacques Girerd
Inorg. Chem. , 2005, 44, 6959-6966 doi : 10.1021/ic048302f

Series of Mn complexes based on N-centered ligands and superoxide - Reactivity in an anhydrous medium and SOD-like activity in an aqueous medium correlated to M-II/Mn-III redox potentials
Stéphanie Durot, Clotilde Policar, Federico Cisnetti, François Lambert, Jean-Philippe Renault, Giorgio Pelosi, Guillaume Blain, Hafsa Korri-Youssoufi, Jean-Pierre Mahy
Eur. J. Inorg. Chem. , 2005, 17, 3513-3523 doi : 10.1002/ejic.200400835

A pulse radiolysis study of catalytic superoxide radical dismutation by a manganese(II) complex with an N-tripodal ligand
Stéphanie Durot, François Lambert, Jean-Philippe Renault, Clotilde Policar
Eur. J. Inorg. Chem. , 2005, 2789-2793 (1ère de couverture) doi : 10.1002/ejic.200400834

Spectroscopic investigation of isonitrile complexes of ferric and ferrous microperoxidase 8
Rémy Ricoux, Sophie Lecomte, Clotilde Policar, Jean-Luc Boucher et Jean-Pierre Mahy
J. Inorg. Biochem. , 2005, 99, 1165-1173 doi : 10.1016/j.jinorgbio.2005.02.012

Imidazole and imidazolate iron complexes: On the way for tuning 3D-structural characteristics and reactivity. Redox interconversions controlled by protonation state
François Lambert, Clotilde Policar, Stéphanie Durot , Michèle Cesario, Lu Yuwei, Hafsa Korri-Youssoufi, Bineta Keita, Louis Nadjo
Inorg. Chem. , 2004, 43, 4178-4188 doi : 10.1021/ic0498687

Structural and magnetic properties of carboxylato-bridged manganese(II) complexes involving tetradentate ligands: Discrete complex and 1D polymers. Dependence of J on the nature of the carboxylato bridge
Stéphanie Durot, Clotilde Policar, Giorgio Pelosi, Franco Bisceglie, Talal Mallah, Jean-Pierre Mahy
Inorg. Chem. , 2003, 42, 8072-8080 doi : 10.1021/ic026130l

Modeling copper(I) complexes: SIBFA molecular mechanics versus ab initio energetics and geometrical arrangements
Nohad Gresh, Clotilde Policar and Claude Giessner-Prettre
J. Chem. Phys. A. , 2002, 106, 5660-5670 doi : 10.1021/jp0106146

The origin of chemical and configurational stability of chiral nonracemic tert-butyl aziridinecarboxylate anions
Valérie Alezra, Martine Bonin, Laurent Micouin, Clotilde Policar and Henri-Philippe Husson
Eur. J. Org. Chem. , 2001, 2589-2594 doi : 10.1002/1099-0690(200107)2001:13<2589::AID-EJOC2589>3.0.CO;2-Y

New Mn-II complexes with an N/O coordination sphere from tripodal N-centered ligands - Characterization from solid state to solution and reaction with superoxide in non-aqueous and aqueous media
Clotilde Policar, Stéphanie Durot, François Lambert, Michèle Cesario, Florence Ramiandrasoa, Irène Morgenstern-Badarau
Eur. J. Inorg. Chem. , 2001, 1807-1818 doi : 10.1002/1099-0682(200107)2001:7<1807::AID-EJIC1807>3.0.CO;2-Y

A polymeric, layered bimetallic Mn(II)Fe(III) imidazolate network; crystal structure and magnetic properties
François Lambert, Jean-Philippe Renault, Clotilde Policar, Irène Morgenstern-Badarau and Michèle Cesario
J. Chem. Soc. Chem. Commun. , 2000, 35-36 doi : 10.1039/a907068k

 An inorganic helix [Mn(IPG)(MeOH)](n)[PF6](n): Structural and magnetic properties of a syn-anti carboxylate-bridged manganese(II) chain involving a tetradentate ligand
Clotilde Policar, François Lambert, Michèle Cesario, Irène Morgenstern-Badarau
Eur. J. Inorg. Chem. , 1999, 2201-2208 doi : 10.1002/(SICI)1099-0682(199912)1999:12<2201::AID-EJIC2201>3.0.CO;2-K

Multifrequency high-field EPR study of binuclear Mn(III)Mn(IV) complexes
Clotilde Policar, Moritz Knüpling, Yves-Michel Frapart, Sun Un
J. Phys. Chem. B , 1998, 102, 10391-10398 doi : 10.1021/jp982096d

First synthesis of a binuclear [Mn-II(bipy)-Fe-III(porphyrin)] complex: Spectroscopic characterization and first evidence of reversible formation of manganese(III) as manganese peroxidase
Clotilde Policar, Isabelle Artaud, Daniel Mansuy
Inorg. Chem. , 1996, 35, 210-216 doi : 10.1021/ic9506771

Synthesis and spectroscopic characterizations of a binuclear [Mn(II)bipyridine-Fe(III)porphyrin] complex first evidence of catalytic production of Mn(III) as model of manganese peroxidase activity
Clotilde Policar, Isabelle Artaud, Daniel Mansuy
J. Inorg. Biochem. , 1995, 59, 625 doi : 10.1021/ma034305k

Le sélénium en biologie humaine
Clotilde Policar
La Gazette Médicale , 1995, 102, 25-28
ref Inist

Le manganèse (Les enjeux de la révolution diététique)
Clotilde Policar
La Gazette Médicale , 1994, 101, n°8, 31-34.
ref Inist

Le zinc en biologie humaine
Clotilde Policar
La Gazette Médicale , 1992, 99, n°28, 53-57
ref Inist

 

Books and books chapter:

AFM-IR: photothermal infrared nanospectroscopy. Application to cellular imaging, A. Dazzi et C. Policar, in Biointerface Characterization by Advanced IR Spectroscopy edited by C.M. Pradier et Y. Chabal, Elsevier, Amsterdam, 2011 (Book chapter upon invitation)

Pourquoi ? CNRS-édition, Paris 2005. Book gathering outreach posteres presented in the parisian metro from 1995 and 2000 under the label Le ticket d’Archimède Clotilde Policar initiated the project and directed it from 1995 to 1999 at the Centre de Vulgarisation de la Connaissance, Université Paris-Sud 11. Le ticket d’Archimède received the first prize Création from the French Research Ministry in 1997

Manganèse (section : le manganèse dans les systèmes biologiques (Manganese in biological systems)
Bernard Dubois, Jacques Fauchère, Gil Michard, Clotilde Policar , Jean-Louis Vignes
Encyclopedia Universalis , 2000
Article

Synthèse organique : une approche expérimentale Alain Fuxa, Thibault Pelletier, Clotilde Policar; Collection Enseignement de la Chimie, Ed. Masson, Paris, décembre 1996, 220 pages.

Popularization of knowledge and Science History

Interview sur France Culture, Emission divers aspects de la pensée contemporaine 22 mai 2016 : Metals in Biology, Pluridisciplinarity, Pleasure of research

Publication of a popularization article about the work of the Inorganic Cellular Chemistry group sin the journal of the Society for Free Radical Biology, december 2014, rubrique Free radicals Abroad. Invitation Pr. I. Batinic-Haberle. (http://www.sfrbm.org/sections/publications/dot)

Penser en trois dimensions : un saut épistémologique en chimie. Clotilde Policar, Symétries, ouvrage collectif interdisciplinaire, Chapitre 4 (pp. 57- 91), Hermès, Paris, 2005 (ouvrage collectif)

Antoine-Laurent Lavoisier : autopsie d'un mythe, Gabriel Gohau, Clotilde Policar, Sciences (revue de l'AFAS), 96-1, 28-32.

Si Lavoisier m'était conté… , entretien avec B. Bensaude-Vincent dans le cadre de l'émission "Divers aspects de la pensée contemporaine" sur France Culture, diffusée le 28-08-94. Publié dans les Cahiers Rationalistes, 1994, 488, 29-32.


 

Patent:

Functionalizable molecular probe for X-ray fluorescence spectroscopy and multimodal imaging
C. Policar, N. Delsuc, F. Lambert, H. Bertrand, A.S. Bernard and S. Hostachy
European patent submitted on July 6, 2015, EP 15 175 553.5
 
Electrogeneration of a catalytic film for producing H2 through water electrolysis
B. Limoges, F. Lambert, F. Mavré, C. Policar,
European patent : 1000266246 (20/11/2014), application number: EP14306849.2 – 1360
 
High frequency deflection measurement of IR absorption
A. Dazzi, V. Konstantin, C. Policar, M. Reading, K. Kjoller, C. Prater
2009 ( 20090249521) , Patent on the AFMIR technique (AFM coupled with an IR laser, use of IR-probes and IR-tagging for IR-mapping of molecules) —with LICENSED — Extension in 2012 : 20120050718
US-Patent : 20090249521