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Membrane tubulation by cell penetrating peptides

Cell penetrating peptides induce membrane invaginations in cellular membranes. They induce negative membrane curvature by a metabolic energy independent pathway. This pathway also called 'Physical endocytosis' could be a new mechanism of cell penetrating peptide uptake

SCoMPIs to Track Molecules Inside Cells

Chem. Commun2012, 48, 7729–7731

Since infrared and luminescent spectroscopies are complementary for bio-detection and bio-imaging, such IR-luminescent SCoMPIs are of great potential and their multiple modalities open up wide prospects for cross correlative studies in biological media. Multimodal imaging is currently a fast expanding field. The elaboration of small molecule chemistry to target and image other organelles and biological macromolecules is likely to contribute substantially to our molecular-level understanding of chemical processes in cells.

Calcium Rubies: A Family of Red-Emitting Functionalizable Indicators

We designed Calcium Rubies, a family of functionalizable BAPTA-based red-fluorescent calcium (Ca2+) indicators as new tools for biological Ca2+ imaging.

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

Gut microbiota metabolises bile acids (BA). As dysbiosis has been reported in inflammatory bowel diseases (IBD), we aim to investigate the impact of IBD associated dysbiosis on BA metabolism and its influence on the epithelial cell inflammation response.

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

Gut microbiota metabolises bile acids (BA). As dysbiosis has been reported in inflammatory bowel diseases (IBD), we aim to investigate the impact of IBD associated dysbiosis on BA metabolism and its influence on the epithelial cell inflammation response.