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An easy-to-detect nona-arginine peptide for epidermal targeting


Chem. Commun., 2015, 51, 2687-2689


A correlative approach combining synchrotron radiation based IR microscopy and fluorescence microscopy enabled the successful detection and quantification of a nona-arginine peptide labelled with a Single Core Multimodal Probe for Imaging (SCoMPI) in skin biopsies. The topical penetration of the conjugate appeared to be time dependent and occurred most probably via the extracellular matrix.



Nanosecond motions in proteins revealed by high-resolution relaxometry

A proper description of biological processes at the atomic level require a full characterization of both the structure and the dynamics of biomolecules. Nuclear magnetic resonance (NMR) is a method of choice to access both to the structure and the dynamics of proteins and nucleic acids. One of most powerful NMR probes of biomolecular dynamics is nuclear spin relaxation. Here, we show that nanosecond time scale motions can be revealed with an emerging technique: high-resolution relaxometry.

Membrane tubulation by cell penetrating peptides

Cell penetrating peptides induce membrane invaginations in cellular membranes. They induce negative membrane curvature by a metabolic energy independent pathway. This pathway also called 'Physical endocytosis' could be a new mechanism of cell penetrating peptide uptake

SCoMPIs to Track Molecules Inside Cells

Chem. Commun2012, 48, 7729–7731

Since infrared and luminescent spectroscopies are complementary for bio-detection and bio-imaging, such IR-luminescent SCoMPIs are of great potential and their multiple modalities open up wide prospects for cross correlative studies in biological media. Multimodal imaging is currently a fast expanding field. The elaboration of small molecule chemistry to target and image other organelles and biological macromolecules is likely to contribute substantially to our molecular-level understanding of chemical processes in cells.

Calcium Rubies: A Family of Red-Emitting Functionalizable Indicators

We designed Calcium Rubies, a family of functionalizable BAPTA-based red-fluorescent calcium (Ca2+) indicators as new tools for biological Ca2+ imaging.